The paper proposes the use of composite endpoint assessments, comprised of soft and hard tissue measurements, to evaluate the effectiveness of periodontal therapies...
Study on Periodontal Therapy Receives Receives R. Earl Robinson Regeneration Award
The paper proposes the use of composite endpoint assessments to evaluate the effectiveness of periodontal therapies.
CHICAGO—October 30, 2007—A study titled New Composite Endpoints to Assess Efficacy in Periodontal Therapy Clinical Trials is the 2007 recipient of the American Academy of Periodontology (AAP) R. Earl Robinson Regeneration Award. Authors of the research are Samuel E. Lynch, Philip T. Lavin, Robert J. Genco, William G. Beasley, and Leslie A. Wisner-Lynch. The paper appeared in the August 2006 issue of the Journal of Periodontology.
The paper proposes the use of composite endpoint assessments, comprised of soft and hard tissue measurements, to evaluate the effectiveness of periodontal therapies. The authors suggest that periodontitis, which affects both soft and hard tissues, lends itself well to the use of a composite assessment since no individual endpoint measurement, including clinical attachment level (CAL) or bone height (clinical or radiographic), has been shown to be more predictive of long-term success. The data for composite endpoint analyses were derived from a multicenter randomized controlled pivotal clinical trial evaluating recombinant human platelet-derived factor-BB (rhPDGF-BB). The paper showed that two composite endpoints which combined assessments of bone regeneration with soft tissue healing met the criteria for successful composite endpoints using historical benchmarks of effectiveness accepted by the US Food and Drug Administration (FDA). This new statistical assessment served in part as the basis for FDA approval of rhPDGF-BB for treatment of periodontal defects.
This award was established by Dr. R. Earl Robinson to encourage research in periodontal regeneration. It is presented to the author(s) of the peer-reviewed published paper that has contributed most to the knowledge of periodontal regeneration in a given calendar year. The research work can be either in the basic or clinical sciences. This award is underwritten by the estate of R. Earl Robinson and sponsored by American Academy of Periodontology Foundation.
About the AAP
The
American Academy of Periodontology is an 8,000-member association of dental professionals specializing in the prevention, diagnosis and treatment of diseases affecting the gums and supporting structures of the teeth and in the placement and maintenance of dental implants. Periodontics is one of nine dental specialties recognized by the American Dental Association.
For more information, contact the AAP Public Affairs Department at 312/573-3242.
